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Proteins/UNIPROT:Q9BXL6
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis..
[Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator..
Function from UniProtKB (Q9BXL6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
9 statements
9 statements · 3 reference databases · Subject: CARD14 · Sources: gene ontology, Hetionet, WikiPathways
3 names
Resolves to: CARD14