Proteins/UNIPROT:Q01954

BNC1

ProteinUNIPROT:Q01954

Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos (By similarity)..

Function from UniProtKB (Q01954), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

46 XX gonadal dysgenesis has a germline basis in BNC1DiseaseGenCC HGNC:1081|MONDO:0009299Inferred only
premature ovarian failure 16 has a germline basis in BNC1DiseaseGenCC HGNC:1081|MONDO:0032881Inferred only

Statements

14 statements

14 statements · 3 reference databases · Subject: BNC1 · Sources: gene ontology, Hetionet, WikiPathways

Order

LHX3 covaries with BNC1ProteinHetionet hetionet:covaries:646-8022Inferred only
SNCB covaries with BNC1ProteinHetionet hetionet:covaries:646-6620Inferred only
SSC5D covaries with BNC1ProteinHetionet hetionet:covaries:284297-646Inferred only
BNC1 interacts with BBC3ProteinHetionet hetionet:interacts:27113-646Inferred only
BID interacts with BNC1ProteinHetionet hetionet:interacts:637-646Inferred only
BIK interacts with BNC1ProteinHetionet hetionet:interacts:638-646Inferred only
BNC1 interacts with HRKProteinHetionet hetionet:interacts:646-8739Inferred only
BNC1 interacts with PICK1ProteinHetionet hetionet:interacts:646-9463Inferred only
BNC1 participates in 15q25 copy number variationPathwayWikiPathways WP5408Inferred only
BNC1 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
BNC1 regulates positive regulation of cell population proliferationBiological processgene ontology Q01954|GO:0008284Inferred only
BNC1 regulates positive regulation of oocyte maturationBiological processgene ontology Q01954|GO:1900195Inferred only

Show the remaining 2

BNC1 regulates positive regulation of transcription by RNA polymerase IBiological processgene ontology Q01954|GO:0045943Inferred only
BNC1 regulates regulation of transcription by RNA polymerase IBiological processgene ontology Q01954|GO:0006356Inferred only

Other names

2 names

Resolves to: BNC1

Also called: BNCZinc finger protein basonuclin-1

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