Proteins/UNIPROT:Q7RTS1

BHLHA15

ProteinUNIPROT:Q7RTS1

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity)..

Function from UniProtKB (Q7RTS1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: BHLHA15 · Sources: gene ontology, Hetionet, Reactome

Order

IFI27 covaries with BHLHA15ProteinHetionet hetionet:covaries:168620-3429Inferred only
MYOD1 interacts with BHLHA15ProteinHetionet hetionet:interacts:168620-4654Inferred only
TCF3 interacts with BHLHA15ProteinHetionet hetionet:interacts:168620-6929Inferred only
BHLHA15 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
BHLHA15 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
BHLHA15 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
BHLHA15 participates in Developmental Lineage of Pancreatic Acinar CellsPathwayReactome R-HSA-9925561Inferred only
BHLHA15 regulates negative regulation of myotube differentiationBiological processgene ontology Q7RTS1|GO:0010832Inferred only
BHLHA15 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q7RTS1|GO:0045944Inferred only

Other names

5 names

Resolves to: BHLHA15

Also called: BHLHB8Class B basic helix-loop-helix protein 8MIST-1MIST1Muscle, intestine and stomach expression 1

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