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Proteins/UNIPROT:Q7Z5W3
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145..
Function from UniProtKB (Q7Z5W3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: BCDIN3D · Sources: gene ontology, Hetionet, Reactome
2 reactions
a 5'-end 5'-phospho-ribonucleoside-RNA+2S-adenosyl-L-methioninea 5'-end (5'-bismethylphospho)-ribonucleoside-RNA+2S-adenosyl-L-homocysteine
Catalysed by BCDIN3D
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:58640CC BY 4.0Reference data
a 5'-end 5'-phospho-ribonucleoside-RNA+S-adenosyl-L-methioninea 5'-end (5'-methylphospho)-ribonucleoside-RNA+S-adenosyl-L-homocysteine
Catalysed by BCDIN3D
Reaction pageDirection not assertedBalance undeterminable
1 name
Resolves to: BCDIN3D