Proteins/UNIPROT:Q9BZZ5

API5

ProteinUNIPROT:Q9BZZ5

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs..

Function from UniProtKB (Q9BZZ5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: API5 · Sources: gene ontology, Hetionet

Order

API5 interacts with ACIN1ProteinHetionet hetionet:interacts:22985-8539Inferred only
API5 interacts with DCUN1D1ProteinHetionet hetionet:interacts:54165-8539Inferred only
FGF2 interacts with API5ProteinHetionet hetionet:interacts:2247-8539Inferred only
PRKAB1 interacts with API5ProteinHetionet hetionet:interacts:5564-8539Inferred only
RAD21 interacts with API5ProteinHetionet hetionet:interacts:5885-8539Inferred only
SUMO1 interacts with API5ProteinHetionet hetionet:interacts:7341-8539Inferred only
UBC interacts with API5ProteinHetionet hetionet:interacts:7316-8539Inferred only
API5 regulates negative regulation of apoptotic processBiological processgene ontology Q9BZZ5|GO:0043066Inferred only

Other names

8 names

Resolves to: API5

Also called: AAC-11Antiapoptosis clone 11 proteinAPI-5Cell migration-inducing gene 8 proteinFibroblast growth factor 2-interacting factorFIFProtein XAGLXAGL

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