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Proteins/UNIPROT:Q6UXT8

ALKAL1

Protein·UNIPROT:Q6UXT8

Open in the graph

Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation. In contrast to ALKAL2, does not act as a potent physiological ligand for ALK..

Function from UniProtKB (Q6UXT8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: ALKAL1 · Sources: gene ontology, Hetionet, Reactome

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ALKAL1 covaries with ARHGEF7ProteinHetionet hetionet:covaries:389658-8874Inferred only
ALKAL1 covaries with COG5ProteinHetionet hetionet:covaries:10466-389658Inferred only
ALKAL1 covaries with ELOBProteinHetionet hetionet:covaries:389658-6923Inferred only
ALKAL1 covaries with PEX10ProteinHetionet hetionet:covaries:389658-5192Inferred only
ALKAL1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ALKAL1 participates in Signaling by ALKPathwayReactome R-HSA-201556Inferred only
ALKAL1 participates in Signaling by LTKPathwayReactome R-HSA-9842663Inferred only
ALKAL1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
ALKAL1 regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q6UXT8|GO:0070374Inferred only
ALKAL1 regulates positive regulation of ERK5 cascadeBiological processgene ontology Q6UXT8|GO:0070378Inferred only
ALKAL1 regulates positive regulation of neuron projection developmentBiological processgene ontology Q6UXT8|GO:0010976Inferred only

Other names

3 names

Resolves to: ALKAL1

Also called: AUG-betaAugmentor betaFAM150A

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