Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P18089

ADRA2B

Protein·UNIPROT:P18089

Open in the graph

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol..

Function from UniProtKB (P18089), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

benign adult familial myoclonic epilepsy has a germline basis in ADRA2BDiseaseGenCC HGNC:282|MONDO:0019448Inferred only

Statements

31 statements

31 statements · 4 reference databases · Subject: ADRA2B · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

ADRA2B covaries with GNAO1ProteinHetionet hetionet:covaries:151-2775Inferred only
ADRA2B interacts with EIF2B1ProteinHetionet hetionet:interacts:151-1967Inferred only
ADRA2B interacts with GNAI2ProteinHetionet hetionet:interacts:151-2771Inferred only
ADRA2B interacts with PPP1R9BProteinHetionet hetionet:interacts:151-84687Inferred only
ADRA2B interacts with UCHL1ProteinHetionet hetionet:interacts:151-7345Inferred only
ADRA2B participates in 2q11 2 copy number variation syndromePathwayWikiPathways WP5221Inferred only
ADRA2B participates in Adrenaline signalling through Alpha-2 adrenergic receptorPathwayReactome R-HSA-392023Inferred only
ADRA2B participates in AdrenoceptorsPathwayReactome R-HSA-390696Inferred only
ADRA2B participates in Amine ligand-binding receptorsPathwayReactome R-HSA-375280Inferred only
ADRA2B participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
ADRA2B participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
ADRA2B participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only

Show the remaining 19

ADRA2B participates in G alpha (z) signalling eventsPathwayReactome R-HSA-418597Inferred only
ADRA2B participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ADRA2B participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
ADRA2B participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
ADRA2B participates in HemostasisPathwayReactome R-HSA-109582Inferred only
ADRA2B participates in Major receptors targeted by epinephrine and norepinephrinePathwayWikiPathways WP4589Inferred only
ADRA2B participates in Monoamine GPCRsPathwayWikiPathways WP58Inferred only
ADRA2B participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
ADRA2B participates in Platelet Aggregation (Plug Formation)PathwayReactome R-HSA-76009Inferred only
ADRA2B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ADRA2B participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ADRA2B regulates negative regulation of epinephrine secretionBiological processgene ontology P18089|GO:0032811Inferred only
ADRA2B regulates negative regulation of norepinephrine secretionBiological processgene ontology P18089|GO:0010700Inferred only
ADRA2B regulates positive regulation of blood pressureBiological processgene ontology P18089|GO:0045777Inferred only
ADRA2B regulates positive regulation of MAPK cascadeBiological processgene ontology P18089|GO:0043410Inferred only
ADRA2B regulates positive regulation of neuron differentiationBiological processgene ontology P18089|GO:0045666Inferred only
ADRA2B regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology P18089|GO:0051897Inferred only
ADRA2B regulates positive regulation of uterine smooth muscle contractionBiological processgene ontology P18089|GO:0070474Inferred only
ADRA2B regulates regulation of vascular associated smooth muscle contractionBiological processgene ontology P18089|GO:0003056Inferred only

Other names

6 names

Resolves to: ADRA2B

Also called: ADRA2L1ADRA2RL1Alpha-2 adrenergic receptor subtype C2Alpha-2B adrenoceptorAlpha-2B adrenoreceptorAlpha-2BAR

← Every protein Find it in the graph →