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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P41586

ADCYAP1R1

Protein·UNIPROT:P41586

Open in the graph

G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract..

Function from UniProtKB (P41586), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

21 statements

21 statements · 4 reference databases · Subject: ADCYAP1R1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ADCYAP1R1 interacts with CALM1ProteinHetionet hetionet:interacts:117-801Inferred only
ADCYAP1R1 interacts with CALM1ProteinHetionet hetionet:interacts:117-808Inferred only
ADCYAP1R1 interacts with CALM1ProteinHetionet hetionet:interacts:117-805Inferred only
ADCYAP1R1 participates in Activation of TRKA receptorsPathwayReactome R-HSA-187015Inferred only
ADCYAP1R1 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
ADCYAP1R1 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
ADCYAP1R1 participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
ADCYAP1R1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ADCYAP1R1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
ADCYAP1R1 participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
ADCYAP1R1 participates in NGF-independant TRKA activationPathwayReactome R-HSA-187024Inferred only
ADCYAP1R1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 9

ADCYAP1R1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ADCYAP1R1 participates in Signaling by NTRK1 (TRKA)PathwayReactome R-HSA-187037Inferred only
ADCYAP1R1 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
ADCYAP1R1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
ADCYAP1R1 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
ADCYAP1R1 regulates positive regulation of calcium ion transport into cytosolBiological processgene ontology P41586|GO:0010524Inferred only
ADCYAP1R1 regulates positive regulation of inositol phosphate biosynthetic processBiological processgene ontology P41586|GO:0060732Inferred only
ADCYAP1R1 regulates positive regulation of small GTPase mediated signal transductionBiological processgene ontology P41586|GO:0051057Inferred only
ADCYAP1R1 regulates regulation of cellular response to oxidative stressBiological processgene ontology P41586|GO:1900407Inferred only

Other names

5 names

Resolves to: ADCYAP1R1

Also called: PAC1 receptorPAC1RPACAP type I receptorPACAP-R-1PACAP-R1

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