Proteins/UNIPROT:O95450

ADAMTS2

ProteinUNIPROT:O95450

Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity..

Function from UniProtKB (O95450), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Ehlers-Danlos syndrome, dermatosparaxis type has a germline basis in ADAMTS2DiseaseGenCC HGNC:218|MONDO:0009161Inferred only

Statements

20 statements

20 statements · 4 reference databases · Subject: ADAMTS2 · Sources: Hetionet, Reactome, UniProt, WikiPathways

Order

KRTAP4-8 covaries with ADAMTS2ProteinHetionet hetionet:covaries:728224-9509Inferred only
ADAMTS2 covaries with MAFBProteinHetionet hetionet:covaries:9509-9935Inferred only
ADAMTS2 covaries with MICOS13ProteinHetionet hetionet:covaries:125988-9509Inferred only
PIK3R1 interacts with ADAMTS2ProteinHetionet hetionet:interacts:5295-9509Inferred only
ADAMTS2 interacts with PIK3R5ProteinHetionet hetionet:interacts:23533-9509Inferred only
ADAMTS2 participates in Collagen biosynthesis and modifying enzymesPathwayReactome R-HSA-1650814Inferred only
ADAMTS2 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
ADAMTS2 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
ADAMTS2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ADAMTS2 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
ADAMTS2 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ADAMTS2 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only

Show the remaining 8

ADAMTS2 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ADAMTS2 participates in Metabolic pathways of fibroblastsPathwayWikiPathways WP5312Inferred only
ADAMTS2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ADAMTS2 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
ADAMTS2 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
ADAMTS2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ADAMTS2 participates in Type I collagen synthesis in the context of osteogenesis imperfectaPathwayWikiPathways WP4786Inferred only
ADAMTS2 requires the cofactor Zn(2+)CompoundUniProt O95450Inferred only

Other names

10 names

Resolves to: ADAMTS2

Also called: ADAM-TS 2ADAM-TS2ADAMTS-2PC I-NPPCINPPCPNIpNPIProcollagen I N-proteinaseProcollagen I/II amino propeptide-processing enzymeProcollagen N-endopeptidase

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