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Proteins/UNIPROT:P63267

ACTG2

Protein·UNIPROT:P63267

Open in the graph

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Function from UniProtKB (P63267), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

familial visceral myopathy has a germline basis in ACTG2DiseaseGenCC HGNC:145|MONDO:0016829Inferred only
megacystis-microcolon-intestinal hypoperistalsis syndrome 1 has a germline basis in ACTG2DiseaseGenCC HGNC:145|MONDO:0100354Inferred only
visceral myopathy 1 has a germline basis in ACTG2DiseaseGenCC HGNC:145|MONDO:0020754Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: ACTG2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ACTG2 interacts with ARRB2ProteinHetionet hetionet:interacts:409-72Inferred only
ACTG2 interacts with EMDProteinHetionet hetionet:interacts:2010-72Inferred only
ACTG2 interacts with MLH1ProteinHetionet hetionet:interacts:4292-72Inferred only
ACTG2 interacts with SHBGProteinHetionet hetionet:interacts:6462-72Inferred only
ACTG2 interacts with UBCProteinHetionet hetionet:interacts:72-7316Inferred only
ACTG2 interacts with UBL4AProteinHetionet hetionet:interacts:72-8266Inferred only
ACTG2 participates in Activation of STAT3 by cadherin engagementPathwayReactome R-HSA-9958825Inferred only
ACTG2 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
ACTG2 participates in Caffeine in myocytesPathwayWikiPathways WP5603Inferred only
ACTG2 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
ACTG2 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
ACTG2 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only

Show the remaining 13

ACTG2 participates in Common pathways underlying drug addictionPathwayWikiPathways WP2636Inferred only
ACTG2 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ACTG2 participates in Formation of the dystrophin-glycoprotein complex (DGC)PathwayReactome R-HSA-9913351Inferred only
ACTG2 participates in Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanismsPathwayWikiPathways WP4534Inferred only
ACTG2 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
ACTG2 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
ACTG2 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
ACTG2 participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
ACTG2 participates in Regulation of CDH1 FunctionPathwayReactome R-HSA-9764561Inferred only
ACTG2 participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
ACTG2 participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
ACTG2 participates in Smooth Muscle ContractionPathwayReactome R-HSA-445355Inferred only
ACTG2 regulates positive regulation of gene expressionBiological processgene ontology P63267|GO:0010628Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

7 names

Resolves to: ACTG2

Also called: [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form]ACTA3ACTL3ACTSGAlpha-actin-3Gamma-2-actinSmooth muscle gamma-actin

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Balanced

Rhea RHEA:13065CC BY 4.0Reference data