RHOBTB1 GTPase cycle

RHOBTB1 is an atypical member of the RHO GTPase family that is predicted not to cycle between a GTP-bound form and a GDP-bound form. RHOBTB family proteins, in contrast to other RHO GTPases, possess other conserved domains in addition to the GTPase domain. The GTPase domain at the N-terminus is followed by a proline-rich region, a tandem of two BTB (broad-complex, tramtrack, bric à brac) domains, and a conserved C-terminal BACK (BTB and C-terminal Kelch) domain. RHOBTB proteins can form homo- and heterodimers, but the role of dimerization in RHOBTB function is not known. RHOBTB1 is highly expressed in skeletal muscle, placenta, stomach, kidney, testis, ovary, uterus and adrenal gland. RHOBTB1 is a component of a signaling cascade that regulates vascular function and blood pressure. RHOBTB1 level is decreased in many cancer types and it is proposed to function as a tumor suppressor, but no mutations in RHOBTB1 have been detected in cancer. RHOBTB1 localizes at early endosomes and participates in the architecture of the endosomal-lysosomal system.

Summary from Reactome (R-HSA-9013422), read 2026-09-23.