Pathway
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
Non-stop mRNAs (mRNAs that lack a stop codon) result in ribosomal stalls proximal to the 3' end of the mRNA, which are resolved by a distinct pathway. In this case, a complex comprising PELO, a paralog of the ribosome release factor eRF1, and HBS1L:GTP, a paralog of the ribosome release factor eRF3:GTP, binds the stalled ribosome near the subunit interface and the mRNA entry site (Shao et al. 2013, and inferred from human PELO:HBS1L and rabbit ribosomes in Pisareva et al. 2011, inferred from yeast homologs DOM34:HBS1 in Shoemaker et al. 2010, Tsuboi et al. 2012, Guydosh and Green 2014, reviewed in Franckenberg et al. 2012). PELO:HBS1L preferentially acts on ribosomes that are bound to mRNAs that have fewer than 12 nucleotides extending 3' of the ribosomal P site.
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HBS1L hydrolyzes GTP and dissociates from PELO and the ribosome, exposing a site on PELO to which ABCE1 binds. ABCE1 then hydrolyzes ATP to cause a conformational change that splits the ribosome into 40S and 60S subunits (Shao et al. 2013, Shao and Hegde 2014, and inferred from the yeast homologs DOM34:HBS1 and archaeal homologs in Becker et al. 2012, inferred from the yeast homologs in Saito et al. 2013). ABCE1 and possibly the mRNA remain bound to the 40S ribosomal subunit, while the peptidyl-tRNA remains bound to the 60S ribosomal subunit as in the ASCC-mediated rescue pathway (Becker et al. 2012, reviewed in Franckenberg et al. 2012).
REACT:R-HSA-9954714Reactome
What the reference databases state
Statements
90 statements
90 statements · 1 reference database · Subject: PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA · Sources: Reactome
- ABCE1 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- FAU participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- PELO participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL10 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL10A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL10L participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL11 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL12 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL13 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL13A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL14 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL15 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
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- RPL17 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL18 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL18A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL19 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL21 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL22 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL22L1 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL23 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL23A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL24 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL26 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL26L1 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL27 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL27A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL28 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL29 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL3 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL30 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL31 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL32 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL34 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL35 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL35A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL36 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL36A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL36AL participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL37 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL37A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL38 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL39 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL39L participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL3L participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL4 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL41 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL5 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL6 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL7 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL7A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL8 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPL9; RPL9P7; RPL9P8; RPL9P9 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPLP0 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPLP1 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPLP2 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS10 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS11 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS12 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS13 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS14 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS15 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS15A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS16 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS17 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS18 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS19 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS2 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS20 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS21 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS23 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS24 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS25 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS26 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS27 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS27A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS27L participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS28 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS29 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS3 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS3A participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS4X participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS4Y1 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS4Y2 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS5 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS6 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS7 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS8 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPS9 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- RPSA participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only
- UBA52 participates in PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNAProteinReactome R-HSA-9954714Inferred only