Pathway
NPAS4 regulates expression of target genes
NPAS4 is a basic helix loop helix (bHLH) transcription factor that needs to dimerize with another bHLH protein, either ARNT, ARNT2 or ARNTL, in order to be able to bind to target DNA.
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NPAS4 is implicated as a transcriptional regulator of genes involved in neuronal development such as CDK5, CDK5R1, RBFOX3 (NeuN), BDNF and RET, genes involved in synaptogenesis and synaptic transmission such as NPTX2, MDM2, FOS, IQSEC3, PLK2 and possibly other genes, circadian rhythm-related genes such as NAMPT, and genes involved in neuroprotection upon injury such as GEM, SYT10 and possibly other genes. In pancreatic beta-cell, NPAS4 is implicated as a regulator of insulin synthesis under stress conditions.
The circadian clock regulated gene CRY1 was identified as NPAS4 target gene in sheep brain. The DBNL gene, encoding Drebrin, a dendrytic cytoskeleton modulator, was identified as a gene directly upregulated by Npas4
NPAS4 is expressed in endothelial cells and may play a role in angiogenesis.
What the reference databases state
Statements
21 statements
21 statements · 1 reference database · Subject: NPAS4 regulates expression of target genes · Sources: Reactome
- ARNT participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- ARNT2 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- BDNF participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- BMAL1 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- CDK5 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- CDK5R1 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- CREBBP participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- FOS participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- GEM participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- INS participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- IQSEC3 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- MAPK1 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
Show the remaining 9
- MAPK3 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- MDM2 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- NAMPT participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- NPAS4 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- PLK2 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- RBFOX3 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- RET participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- SYT10 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only
- XPO1 participates in NPAS4 regulates expression of target genesProteinReactome R-HSA-9768919Inferred only