Pathway
Intracellular metabolism of fatty acids regulates insulin secretion
Fatty acids augment the glucose triggered secretion of insulin through two mechanisms: activation of FFAR1 (GPR40) and intracellular metabolism of fatty acids. Fatty acids are transported into the cell by CD36 (FAT) and metabolized by ligation to coenzyme A, transport into mitochondria, and beta oxidation which generates ATP. The ATP increases the intracellular ratio of ATP:ADP and thereby closes potassium channels (K(ATP) channels) at the plasma membrane (reviewed in Acosta-Montano and Garcia-Gonzalez 2018). The enzymes that metabolize fatty acids in beta cells also metabolize fatty acids in other tissues however their combinations and subcellular locations may differ.
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: Intracellular metabolism of fatty acids regulates insulin secretion · Sources: Reactome
- ACSL3 participates in Intracellular metabolism of fatty acids regulates insulin secretionProteinReactome R-HSA-434313Inferred only
- ACSL4 participates in Intracellular metabolism of fatty acids regulates insulin secretionProteinReactome R-HSA-434313Inferred only
- CD36 participates in Intracellular metabolism of fatty acids regulates insulin secretionProteinReactome R-HSA-434313Inferred only