Pathway
DNA Damage Recognition in GG-NER
In global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DNA helix and recognizes damage that disrupts normal Watson-Crick base pairing, which results in binding of the XPC:RAD23:CETN2 complex to the undamaged DNA strand. The second complex is a ubiquitin ligase UV-DDB that consists of DDB2, DDB1, CUL4A or CUL4B and RBX1. The UV-DDB complex is necessary for the recognition of UV-induced DNA damage and may contribute to the retention of the XPC:RAD23:CETN2 complex at the DNA damage site. The UV-DDB complex binds the damaged DNA strand.
REACT:R-HSA-5696394Reactome
What the reference databases state
Statements
38 statements
38 statements · 1 reference database · Subject: DNA Damage Recognition in GG-NER · Sources: Reactome
- ACTB participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- ACTL6A participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- ACTR5 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- ACTR8 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- CETN2 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS2 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS3 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS4 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS5 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS6 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS7A participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- COPS7B participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
Show the remaining 26
- COPS8 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- CUL4A participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- CUL4B participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- DDB1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- DDB2 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- GPS1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- INO80 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- INO80B participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- INO80C participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- INO80D participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- INO80E participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- MCRS1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- NFRKB participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- PARP1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- PARP2 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- RAD23A participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- RAD23B participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- RBX1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- RPS27A participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- RUVBL1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- TFPT participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- UBA52 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- UBB participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- UBC participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- XPC participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only
- YY1 participates in DNA Damage Recognition in GG-NERProteinReactome R-HSA-5696394Inferred only