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Reach

1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

74 compounds within 3 steps: 4 in 1, 14 in 2, 56 in 3

Does it reach a compound?

Three steps

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 3 more
(9Z,12Z)-octadecadien-1-olReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate
3. 9-hydroxy-octadecanoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 9-(9Z-octadecenoyloxy)-octadecanoate + 2-(9Z-octadecenoyl)-glycerol
Catalysed by PNPLA2
(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 4 more
1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 4 morecytosolOne of 2 routes
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 6 more
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 2 more
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. a 1-acyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 2 more
2,3-di-(9Z)-octadecenoyl-sn-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol
Catalysed by PNPLA2One of 2 routes
2,3-di-(9Z)-hexadecenoyl-sn-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate
3. 1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate
Catalysed by PNPLA2
1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate
3. 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate
Catalysed by PNPLA2
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 1 more
(2E,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
3. (9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]
Catalysed by PNPLA2, ACSL3, ACSBG2, SLC27A3 and 3 more
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
3. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by PNPLA2, PLA2G6, PNPLA8
9-hexadecanoyloxy-octadecanoateReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate
3. 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 9-hexadecanoyloxy-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol
Catalysed by PNPLA2
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)
3. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by PNPLA2, ABHD16A
13-oxo-(9Z,11E)-octadecadienoateReach from here →
1. 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)
2. (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O
Catalysed by PNPLA2, ALOX15, ALOX12, CYP1A1 and 4 more

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