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CompoundsSubstances with curated findings
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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Reference

Evidence

Compounds
Outcomes
Proteins
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Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Reach

eicosanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

355 compounds within 3 steps: 2 in 1, 39 in 2, 314 in 3

Does it reach a compound?

Three steps

(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
Catalysed by PTGS2cytosol, extracellular space
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
Catalysed by PTGS2cytosol, extracellular space
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
Catalysed by ALOX15Bcytosol, extracellular space
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
Catalysed by ALOX15Bcytosol, extracellular space
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
Catalysed by PTGS2cytosol, extracellular space

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