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Catalyst

pyridoxal 5'-phosphateFinding

Pyridoxal 5'-phosphate decreases incidence of myocardial infarction

lowersVery limited evidenceFinding

01 · The sentence it was drawn from

“Myocardial infarctions with peak creatinine kinase-myocardial band> or =100 ng/mL were reduced by 47.2% in the MC-1 250-mg group versus placebo (P = .0083).”
Quoted verbatim from Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study.
This finding among the 10 findings on its endpoint

pyridoxal 5'-phosphate

Incidence of myocardial infarction

lowers

Who
High-risk patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass; MC-1 250 mg arm against placebo, myocardial infarction defined as peak CK-MB at least 100 ng/mL
Dose studied
MC-1 (pyridoxal-5'-phosphate monohydrate) 250 mg once daily from 3 to 10 hours before surgery to postoperative day 30

Very limited evidencePMID 17532963 · 2007

02 · The study

Study
RCT
Duration
4 weeks

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

The Journal of thoracic and cardiovascular surgery
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M70510R2MRF5KQNS3GFH0S4V