L-citrulline increases plasma arginine concentration

raisesVery limited evidenceFindingreplicated ×2

01 · The sentence it was drawn from

“Plasma citrulline concentration rose 17-fold (25 ± 9 vs. 384 ± 95 μmol/L) and plasma arginine 3-fold after oral citrulline supplementation (both p < 4 × 10-6).”

Quoted verbatim from Effect of oral citrulline supplementation on whole body protein metabolism in adult patients with short bowel syndrome: A pilot, randomized, double-blind, cross-over study.

This finding among the 4 findings on its endpoint

L-citrulline

Plasma arginine concentration

raises

Who: Nine adults with non-malignant short bowel syndrome, near-normal nutritional status, without artificial nutrition; postabsorptive state
Dose studied: 0.18 g/kg/day oral citrulline for 7 days; iso-nitrogenous placebo, 13-day washout

Very limited evidencePMID 30642738 · 2019

02 · The study

Study: crossover
Duration: 7 days

Evidence, by strength

strong
moderate
limited
very limitedthis finding
insufficient

03 · The paper

Clinical nutrition (Edinburgh, Scotland)

Effect of oral citrulline supplementation on whole body protein metabolism in adult patients with short bowel syndrome: A pilot, randomized, double-blind, cross-over study.

2019PMID 30642738doi 10.1016/j.clnu.2018.12.030

What else it reported2 findings · 1 compound · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZFAV89MHD2XFNXNE38J8X5