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Catalyst

N(5)-ethyl-L-glutamineFinding

N(5)-ethyl-L-glutamine has no detected effect on Insomnia Severity Index (ISI) total score

no difference foundVery limited evidenceFinding

01 · The sentence it was drawn from

“Results revealed that adjunctive L-theanine did not outperform placebo for anxiety reduction on the HAMA (p = 0.73) nor insomnia severity on the Insomnia Severity Index (ISI; p = 0.35).”
Quoted verbatim from L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
This finding among the 2 findings on its endpoint

N(5)-ethyl-L-glutamine

Insomnia Severity Index (ISI) total score

no difference found

Who
Adults with DSM-5 generalized anxiety disorder, all on stable antidepressant treatment in both arms
Dose studied
adjunctive L-theanine 450-900 mg

Very limited evidencePMID 30580081 · 2019

02 · The study

Study
RCT
Duration
8 weeks

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

Journal of psychiatric research
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZBMX5PX1EQ7F4AZKHQSCZ9