Milk thistle extract (silymarin) has no detected effect on alanine aminotransferase

no difference foundModerate evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Median (interquartile range, IQR) of ALT levels in the silymarin and placebo groups were 32 (20, 184) and 35 (15, 415) IU/L, which were not significantly different (p = 0.455).”

Quoted verbatim from A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.

This finding among the 65 findings on its endpoint

milk thistle extract (silymarin)

Alanine aminotransferase

no difference found

Who: Adults with newly diagnosed pulmonary tuberculosis, all receiving isoniazid, rifampicin, pyrazinamide and ethambutol; ALT at week 4
Dose studied: 140 mg three times daily with the antituberculosis drugs

Moderate evidencePMID 26400476 · 2015

02 · The study

Study: RCT
Duration: 4 weeks

Evidence, by strength

strong
moderatethis finding
limited
very limited
insufficient

03 · The paper

BMC complementary and alternative medicine

A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.

2015PMID 26400476doi 10.1186/s12906-015-0861-7Industry funded

What else it reported1 finding · 0 compounds · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6Y292VH5RM6XKZKW6HPSFEZ