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milk thistle extract (silymarin)Finding

Milk thistle extract (silymarin) has no detected effect on alanine aminotransferase

no difference foundModerate evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Furthermore, there was no statistically significant difference across treatment groups (P=.75) when changes in serum ALT levels from baseline to end of treatment were analyzed as a continuous variable (mean decline, −4.3 [95% CI, −17.3 to 8.7] U/L for placebo, −14.4 [95% CI, −41.6 to 12.7] U/L for 420-mg silymarin, and −11.3 [95% CI, −27.9 to 5.4] U/L for 700-mg silymarin).”
Quoted verbatim from Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial.
This finding among the 65 findings on its endpoint

milk thistle extract (silymarin)

Alanine aminotransferase

no difference found

Who
Adults with chronic hepatitis C who had not responded to interferon-based therapy and had serum ALT of 65 U/L or greater; three-group comparison of silymarin 420 mg, silymarin 700 mg and placebo; change in ALT from baseline to end of treatment
Dose studied
420 mg or 700 mg silymarin three times daily for 24 weeks

Moderate evidencePMID 22797645 · 2012

02 · The study

Study
RCT
Duration
6 months

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

JAMA
What else it reported2 findings · 0 compounds · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6Y291M3S40JE2AQS1CEWMDV