dapagliflozin/Finding
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Depletes lactate
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Dapagliflozin treatment markedly reduced blood glucose, urinary albumin to creatinine ratio (UACR), and renal cortical lactate levels in a dose-dependent manner.”
Quoted verbatim from Dapagliflozin May Attenuate Podocyte Injury in Diabetic Kidney Disease through Inhibition of Lactate-Mediated H4K12 Lactylation.. - Study
- animal · not in humans
- Population
- male db/db mice given dapagliflozin 4 or 8 mg/kg/day by oral gavage for 10 weeks, against untreated db/db mice
Dapagliflozin May Attenuate Podocyte Injury in Diabetic Kidney Disease through Inhibition of Lactate-Mediated H4K12 Lactylation.2026PMID:42030222Permalink
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To cite this finding: https://catalystproject.ai/e/01M4PNCQ69FY25K8EPRKRYNC2A