berberine/Finding
One finding, on its own
A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits CYP3A4
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“CYP3A4 activity was also inhibited, as the Cmax, AUC0–∞, and AUC0–12 of mid-azolam were increased 38% (P<0.05), 40% (P<0.01), and 37% (P<0.05) after BBR treatment.”
Quoted verbatim from Repeated administration of berberine inhibits cytochromes P450 in humans.. - Study
- crossover
- Duration
- 14 days
- Dose
- berberine 300 mg three times daily orally for 14 days versus placebo; midazolam 2 mg probe
- Population
- Healthy Chinese male volunteers, randomised two-phase crossover with 4-week washout; CYP3A4 activity read from midazolam pharmacokinetics (in vivo probe)
Repeated administration of berberine inhibits cytochromes P450 in humans.2012PMID:21870106Permalink
Keep reading
- Everything the graph holds on berberine
- Every compound studied against CYP3A4
- How to read the evidence strength and the marks
To cite this finding: https://catalystproject.ai/e/01M456WJHJE3FZJ9FGG71KYPPW