sertraline/Finding
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Increases congenital cardiovascular malformation incidence (offspring)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Pregnant women who used sertraline in the first trimester had a statistically significant increased risk of infant cardiovascular-related malformations (OR = 1.36; 95% CI = 1.06-1.74; I2 = 64.4%; n = 12) as well as atrial and/or ventricular septal defects (OR = 1.36, 95% CI = 1.06-1.76; I2 = 62.2%; n = 8).”
Quoted verbatim from Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.. - Study
- meta-analysis
- Population
- Infants of pregnant women exposed to sertraline in the first trimester; meta-analysis of 12 cohort studies
Effect 1.36 odds ratio, 95% CI 1.06 to 1.74
Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.2017PMID:27770542Permalink
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To cite this finding: https://catalystproject.ai/e/01M456VCPMYN1WBWWYZ1MJZ9X2