thrombotic thrombocytopenic purpura
Findings
No curated finding names thrombotic thrombocytopenic purpura yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Thrombotic thrombocytopenic purpura (TTP) is an aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of congenital TTP and acquired TTP.
Definition from the Mondo Disease Ontology (MONDO:0018896), read 2026-09-29. CC BY 4.0.
Features
22 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- DyspneaHPOHP:0002094
- Very frequent (80% to 99% of cases)
- Generalized muscle weaknessHPOHP:0003324
- Very frequent (80% to 99% of cases)
- Microangiopathic hemolytic anemiaHPOHP:0001937
- Very frequent (80% to 99% of cases)
- ReticulocytosisHPOHP:0001923
- Very frequent (80% to 99% of cases)
- ThrombocytopeniaHPOHP:0001873
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormal circulating lactate dehydrogenase concentrationHPOHP:0045040
- Frequent (30% to 79% of cases)
- ComaHPOHP:0001259
- Frequent (30% to 79% of cases)
- ConfusionHPOHP:0001289
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- SeizureHPOHP:0001250
- Frequent (30% to 79% of cases)
Show the remaining 10
- StrokeHPOHP:0001297
- Frequent (30% to 79% of cases)
- Abnormality of the nervous systemHPOHP:0000707
- Occasional (5% to 29% of cases)
- ArrhythmiaHPOHP:0011675
- Occasional (5% to 29% of cases)
- FeverHPOHP:0001945
- Occasional (5% to 29% of cases)
- HematuriaHPOHP:0000790
- Occasional (5% to 29% of cases)
- Myocardial infarctionHPOHP:0001658
- Occasional (5% to 29% of cases)
Where it sits
Other names
3 names
Resolves to: thrombotic thrombocytopenic purpura
- Also called
- Moschcowitz diseaseMoschowitz diseaseTTP