acquired thrombotic thrombocytopenic purpura
Findings
No curated finding names acquired thrombotic thrombocytopenic purpura yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acquired thrombotic thrombocytopenic purpura is the non-hereditary form of thrombotic thrombocytopenic purpura (TTP), characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity.
Definition from the Mondo Disease Ontology (MONDO:0019740), read 2026-09-29. CC BY 4.0.
Features
41 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anti-ADAMTS13 antibody positivityHPOHP:6000462
- Very frequent (80% to 99% of cases)
- Microangiopathic hemolytic anemiaHPOHP:0001937
- Very frequent (80% to 99% of cases)
- PurpuraHPOHP:0000979
- Very frequent (80% to 99% of cases)
- ThrombocytopeniaHPOHP:0001873
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- ArthralgiaHPOHP:0002829
- Frequent (30% to 79% of cases)
- ComaHPOHP:0001259
- Frequent (30% to 79% of cases)
- ConfusionHPOHP:0001289
- Frequent (30% to 79% of cases)
- Decreased circulating haptoglobin concentrationHPOHP:0020181
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- DyspneaHPOHP:0002094
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
Show the remaining 29
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- HematuriaHPOHP:0000790
- Frequent (30% to 79% of cases)
- HyperbilirubinemiaHPOHP:0002904
- Frequent (30% to 79% of cases)
- Increased circulating lactate dehydrogenase concentrationHPOHP:0025435
- Frequent (30% to 79% of cases)
- Increased circulating troponin I concentrationHPOHP:0410173
- Frequent (30% to 79% of cases)
Where it sits
Other names
3 names
Resolves to: acquired thrombotic thrombocytopenic purpura
- Also called
- acquired ADAMTS13 deficiencyacquired TTPautoimmune thrombotic thrombocytopenic purpura