spermatogenic failure, X-linked, 2
Findings
No curated finding names spermatogenic failure, X-linked, 2 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any azoospermia in which the cause of the disease is a mutation in the TEX11 gene.
Definition from the Mondo Disease Ontology (MONDO:0010647), read 2026-09-29. CC BY 4.0.
- Inheritance
- X-linked recessive inheritance
- Onset and course
- Young adult onset
HPO, annotations 2026-09-02
Features
4 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AzoospermiaHPOHP:0000027
- 7 of 7 reported patients
- Male infertilityHPOHP:0003251
- 7 of 7 reported patients
- Spermatogenesis maturation arrestHPOHP:0031038
- 5 of 5 reported patients
- Testicular atrophyHPOHP:0000029
- 2 of 7 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TEX11HGNC:11733
- Strong · Labcorp Genetics (formerly Invitae) · X-linked · 2023
- Moderate · Ambry Genetics · X-linked · 2018
Where it sits
- A kind of
Other names
4 names
Resolves to: spermatogenic failure, X-linked, 2
- Also called
- azoospermia caused by mutation in TEX11spermatogenic failure, X-linked, 2, X-linked recessivespermatogenic failure, X-linked, type 2TEX11 azoospermia