spermatogenic failure 28
MONDO:0054732Mondo
Findings
No curated finding names spermatogenic failure 28 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal recessive inheritance
- Onset and course
- Young adult onset
HPO, annotations 2026-09-02
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased testicular sizeHPOHP:0008734
- 3 of 3 reported patients
- Elevated circulating follicle stimulating hormone levelHPOHP:0008232
- 3 of 3 reported patients
- Male infertilityHPOHP:0003251
- 3 of 3 reported patients
- Non-obstructive azoospermiaHPOHP:0011961
- 3 of 3 reported patients
- Elevated circulating luteinizing hormone levelHPOHP:0011969
- 2 of 3 reported patients
- Decreased serum testosterone concentrationHPOHP:0040171
- 1 of 3 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FANCMHGNC:23168
- Strong · Ambry Genetics · Autosomal recessive · 2022
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2020
- Strong · PanelApp Australia · Autosomal recessive · 2025
Where it sits
- A kind of