spermatogenic failure 12
MONDO:0014172Mondo
Findings
No curated finding names spermatogenic failure 12 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any azoospermia in which the cause of the disease is a mutation in the NANOS1 gene.
Definition from the Mondo Disease Ontology (MONDO:0014172), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
HPO, annotations 2026-09-02
Features
3 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal male germ cell morphologyHPOHP:0012863
- AzoospermiaHPOHP:0000027
- InfertilityHPOHP:0000789
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- NANOS1HGNC:23044
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2020
Where it sits
Other names
3 names
Resolves to: spermatogenic failure 12
- Also called
- azoospermia caused by mutation in NANOS1NANOS1 azoospermiaspermatogenic failure type 12