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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Disease

severe ichthyosis vulgaris

MONDO:0100475Mondo

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Findings

No curated finding names severe ichthyosis vulgaris yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

An instance of ichthyosis vulgaris in which the disease presentation is severe in severity. Homozygous FLG mutation carriers often have more severe manifestations.

Definition from the Mondo Disease Ontology (MONDO:0100475), read 2026-09-29. CC BY 4.0.

Where it sits

A kind of: autosomal dominant ichthyosis vulgaris