autosomal dominant ichthyosis vulgaris
Findings
No curated finding names autosomal dominant ichthyosis vulgaris yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Ichthyosis vulgaris is a common skin disorder passed down through families that leads to dry, scaly skin. It often begins in early childhood. Treatment may include heavy duty moisturizers which contain chemicals that help the skin to shed normally, including lactic acid, salicylic acid, and urea. Ichthyosis vulgaris can be a nuisance, but it rarely affects overall health. The condition usually disappears during adulthood, but may return in later years. This condition is inherited in an autosomal dominant pattern.
Definition from the Mondo Disease Ontology (MONDO:0007810), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance · Autosomal recessive inheritance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
7 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Absent keratohyalin granulesHPOHP:0033807
- 1 of 1 reported patient
- AsthmaHPOHP:0002099
- Frequent (30% to 79% of cases)
- Eczematoid dermatitisHPOHP:0000964
- Frequent (30% to 79% of cases)
- Dry skinHPOHP:0000958
- IchthyosisHPOHP:0008064
- Keratosis pilarisHPOHP:0032152
- Palmar hyperlinearity
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FLGHGNC:3748
- Definitive · Laboratory for Molecular Medicine · Semidominant · 2020
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2020
- Limited · G2P · Autosomal recessive · 2017
Where it sits
- Narrower terms (2)
Other names
1 name
Resolves to: autosomal dominant ichthyosis vulgaris
- Also called
- ichthyosis vulgaris, autosomal dominant