sarcoma
Findings
No curated finding names sarcoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.
Definition from the Mondo Disease Ontology (MONDO:0005089), read 2026-09-29. CC BY 4.0.
Genes
6 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TP53HGNC:11998
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- APCHGNC:583
- Moderate · Genomics England PanelApp · Autosomal dominant · 2021
- ATMHGNC:795
- Moderate · Genomics England PanelApp · Autosomal dominant · 2021
- ATRHGNC:882
- Moderate · Genomics England PanelApp · Autosomal dominant · 2021
- BRCA2HGNC:1101
- Moderate · Genomics England PanelApp · Autosomal dominant · 2021
- ERCC2HGNC:3434
- Moderate · Genomics England PanelApp · Autosomal recessive · 2021
Where it sits
- A kind of
- Narrower terms (22)
- bone sarcoma
- chondrosarcoma
- colon sarcoma
- dendritic cell sarcoma
- ectomesenchymoma
- endometrioid stromal sarcoma
- Ewing sarcoma
- giant cell tumor of soft tissue
- lymphangiosarcoma
- mast cell sarcoma
- myeloid sarcoma
- orbit sarcoma
- osteosarcoma
- rectum sarcoma
- reticulum cell sarcoma
- sarcoma G1
- sarcoma of cervix uteri
- sarcomatosis
- small cell sarcoma
- soft tissue sarcoma
- spindle cell sarcoma
- uterine corpus sarcoma
Other names
4 names
Resolves to: sarcoma
- Also called
- mesenchymal tumor, malignantsarcoma of soft tissue and bonesarcoma of the soft tissue and bonesarcoma, malignant