rheumatoid arthritis
Findings
No curated finding names rheumatoid arthritis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Definition from the Mondo Disease Ontology (MONDO:0008383), read 2026-09-29. CC BY 4.0.
Features
18 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anti-citrullinated protein antibody positivityHPOHP:0033034
- ArthralgiaHPOHP:0002829
- ArthritisMondoHP:0001369
- AutoimmunityMondoHP:0002960
- Digital flexor tenosynovitisHPOHP:0012276
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Elevated erythrocyte sedimentation rateHPOHP:0003565
- FatigueHPOHP:0012378
- FeverHPOHP:0001945
- Interphalangeal joint erosionsHPOHP:0006252
- Joint stiffnessHPOHP:0001387
- Joint swellingHPOHP:0001386
Show the remaining 6
- Polyarticular arthritisHPOHP:0005764
- Rheumatoid arthritisHPOHP:0001370
- Rheumatoid factor positiveHPOHP:0002923
- Swan neck-like deformities of the fingersHPOHP:0006150
- VasculitisHPOHP:0002633
- Weight lossHPOHP:0001824
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- PTPN22HGNC:9652
- Limited · Laboratory for Molecular Medicine · Unknown · 2020
Where it sits
Other names
1 name
Resolves to: rheumatoid arthritis
- Also called
- RA