primary progressive freezing gait
Findings
No curated finding names primary progressive freezing gait yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Primary progressive freezing gait is a rare, heterogeneous, progressively incapacitating neurodegenerative disease characterized by freezing of gait (usually during the first 3 years), later associating postural instability, eventually resulting in a wheelchair-bound state. Other features may include mild bradykinesia, rigidity, postural tremor, hyperreflexia, speech disorder and dementia. The disease is unresponsive to dopaminergic treatments.
Definition from the Mondo Disease Ontology (MONDO:0019160), read 2026-09-29. CC BY 4.0.
Features
21 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Frequent fallsHPOHP:0002359
- Very frequent (80% to 99% of cases)
- Gait disturbanceHPOHP:0001288
- Very frequent (80% to 99% of cases)
- Postural instabilityHPOHP:0002172
- Very frequent (80% to 99% of cases)
- Abnormal speech patternHPOHP:0002167
- Frequent (30% to 79% of cases)
- BradykinesiaHPOHP:0002067
- Frequent (30% to 79% of cases)
- ClonusHPOHP:0002169
- Frequent (30% to 79% of cases)
- Hyperreflexia
Show the remaining 9
- DementiaHPOHP:0000726
- Occasional (5% to 29% of cases)
- DysphagiaHPOHP:0002015
- Occasional (5% to 29% of cases)
- Gait imbalanceHPOHP:0002141
- Occasional (5% to 29% of cases)
- Impaired smooth pursuitHPOHP:0007772
- Occasional (5% to 29% of cases)
- Lewy bodiesHPOHP:0100315
- Occasional (5% to 29% of cases)
- Restless legsHPOHP:0012452
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: primary progressive freezing gait
- Also called
- PPFG