primary membranoproliferative glomerulonephritis
Findings
No curated finding names primary membranoproliferative glomerulonephritis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare glomerular disease characterized by a pattern of glomerular injury on kidney biopsy with characteristic light microscopic changes: mesangial hypercellularity, endocapillary proliferation, and thickening of the glomerular basement membrane (GBM). On the basis of immunofluorescence (IF) the disorder is divided into C3 glomerulopathy (C3G) or immunoglobulin-mediated membranoproliferative glomerulonephritis. Through electron microscopy C3G is further divided into Dense deposit disease, with highly electrondense deposits in the glomerular basement membrane, and C3 glomerulonephritis, with mesangial, intramembranous, subendothelial and subepithelial deposits. Secondary causes (autoimmune, infectious, malignancies) are excluded.
Definition from the Mondo Disease Ontology (MONDO:0018904), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Membranoproliferative glomerulonephritisHPOHP:0000793
- Very frequent (80% to 99% of cases)
- C3 nephritic factor positivityHPOHP:0030888
- Frequent (30% to 79% of cases)
- Chronic kidney diseaseHPOHP:0012622
- Frequent (30% to 79% of cases)
- Decreased circulating complement C3 concentrationHPOHP:0005421
- Frequent (30% to 79% of cases)
- Glomerular subendothelial electron-dense depositsHPOHP:0004746
- Frequent (30% to 79% of cases)
- HypertensionHPOHP:0000822
- Frequent (30% to 79% of cases)
Show the remaining 4
- Stage 5 chronic kidney diseaseHPOHP:0003774
- Occasional (5% to 29% of cases)
- Abnormal thrombosisHPOHP:0001977
- Very rare (1% to 4% of cases)
- DrusenHPOHP:0011510
- Very rare (1% to 4% of cases)
- Myocardial infarctionHPOHP:0001658
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: primary membranoproliferative glomerulonephritis
- Also called
- Mesangiocapillary glomerulonephritisMPGN