complement 3 glomerulopathy
MONDO:0018013Mondo
Findings
No curated finding names complement 3 glomerulopathy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare primary membranoproliferative glomerulonephritis characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples.
Definition from the Mondo Disease Ontology (MONDO:0018013), read 2026-09-29. CC BY 4.0.
Features
23 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HematuriaHPOHP:0000790
- Very frequent (80% to 99% of cases)
- C3 nephritic factor positivityHPOHP:0030888
- Frequent (30% to 79% of cases)
- Chronic kidney diseaseHPOHP:0012622
- Frequent (30% to 79% of cases)
- Decreased circulating complement C3 concentrationHPOHP:0005421
- Frequent (30% to 79% of cases)
- Elevated circulating creatinine concentrationHPOHP:0003259
- Frequent (30% to 79% of cases)
- HypertensionHPOHP:0000822
- Frequent (30% to 79% of cases)
- Membranoproliferative glomerulonephritisHPOHP:0000793
- Frequent (30% to 79% of cases)
- Mesangial hypercellularityHPOHP:0012574
- Frequent (30% to 79% of cases)
- Nephrotic range proteinuriaHPOHP:0012593
- Frequent (30% to 79% of cases)
- ProteinuriaHPOHP:0000093
- Frequent (30% to 79% of cases)
- Stage 5 chronic kidney diseaseHPOHP:0003774
- Frequent (30% to 79% of cases)
- Abnormal dark-adapted electroretinogramHPOHP:0030469
- Occasional (5% to 29% of cases)
Show the remaining 11
- Acute kidney injuryHPOHP:0001919
- Occasional (5% to 29% of cases)
- Anti-Complement factor H antibody positivityHPOHP:0034001
- Occasional (5% to 29% of cases)
- AutoimmunityHPOHP:0002960
- Occasional (5% to 29% of cases)
- Crescentic glomerulonephritisHPOHP:0008653
- Occasional (5% to 29% of cases)
- Decreased circulating complement C4 concentrationHPOHP:0045042
- Occasional (5% to 29% of cases)
- DrusenHPOHP:0011510
- Occasional (5% to 29% of cases)
Where it sits
- Narrower terms (3)
Other names
6 names
Resolves to: complement 3 glomerulopathy
- Also called
- C3 glomerulopathyC3Gnon-Ig-mediated membranoproliferative glomerulonephritisnon-Ig-mediated MPGNnon-immunoglobulin-mediated membranoproliferative glomerulonephritisnon-immunoglobulin-mediated MPGN