periodontitis, aggressive 1
Findings
No curated finding names periodontitis, aggressive 1 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A localized aggressive periodontitis, formerly called localized juvenile periodontitis. It is a destructive form of periodontitis characterized by ALVEOLAR BONE LOSS of the MOLARS and INCISORS. Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Definition from the Mondo Disease Ontology (MONDO:0008226), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
HPO, annotations 2026-09-02
Features
4 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Severe periodontitisHPOHP:0000166
- 4 of 4 reported patients · Infantile onset
- Palmoplantar hyperkeratosisHPOHP:0000972
- 0 of 4 reported patients
- Gingival recessionHPOHP:0030816
- Spontaneous tooth lossHPOHP:0006480
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CTSCHGNC:2528
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2020
Where it sits
Other names
2 names
Resolves to: periodontitis, aggressive 1
- Also called
- periodontitis 1, juvenileperiodontitis, aggressive, type 1