pellagra
Findings
No curated finding names pellagra yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Pellagra is a nutritional disorder caused by a deficiency in niacin (vitamin B3) or its precursor (tryptophan) that is mainly observed in Asia and Africa where it is generally due to poor nutrition. It is characterized by dermatitis (symmetrical photodistributed erythema that may be accompanied by vesicles and bullae, and that develops into hyperkeratotic and hyperpigmented skin), gastrointestinal symptoms (diarrhea), and neuropsychiatric disorders (dementia). It can be life-threatening without a correct management.
Definition from the Mondo Disease Ontology (MONDO:0019975), read 2026-09-29. CC BY 4.0.
Features
43 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased circulating vitamin B3 concentrationHPO · MondoHP:0100497
- Very frequent (80% to 99% of cases)
- Abnormal blistering of the skinHPOHP:0008066
- Frequent (30% to 79% of cases)
- CachexiaHPOHP:0004326
- Frequent (30% to 79% of cases)
- CheilitisHPOHP:0100825
- Frequent (30% to 79% of cases)
- Cognitive impairmentHPOHP:0100543
- Frequent (30% to 79% of cases)
- Cutaneous photosensitivityHPOHP:0000992
- Frequent (30% to 79% of cases)
- Delirium
Show the remaining 31
- GastritisHPOHP:0005263
- Frequent (30% to 79% of cases)
- GlossitisHPOHP:0000206
- Frequent (30% to 79% of cases)
- HallucinationsHPOHP:0000738
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- HyperkeratosisHPOHP:0000962
- Frequent (30% to 79% of cases)
- Irregular hyperpigmentationHPOHP:0007400
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- KMOHGNC:6381
- Limited · PanelApp Australia · Autosomal recessive · 2025
- No Known Disease Relationship · ClinGen · Autosomal recessive · 2023