ovarian hyperstimulation syndrome
Findings
No curated finding names ovarian hyperstimulation syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A complication of ovulation induction in infertility treatment. It is graded by the severity of symptoms which include ovary enlargement, multiple ovarian follicles; ovarian cysts; ascites; and generalized edema. The full-blown syndrome may lead to renal failure, respiratory distress, and even death. Increased capillary permeability is caused by the vasoactive substances, such as vascular endothelial growth factors, secreted by the overly-stimulated ovaries.
Definition from the Mondo Disease Ontology (MONDO:0011972), read 2026-09-29. CC BY 4.0.
Features
17 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abdominal distentionHPOHP:0003270
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Very frequent (80% to 99% of cases)
- AscitesHPOHP:0001541
- Very frequent (80% to 99% of cases)
- Capillary leakHPOHP:0030005
- Very frequent (80% to 99% of cases)
- Enlarged polycystic ovariesHPOHP:0008675
- Very frequent (80% to 99% of cases)
- HirsutismHPOHP:0001007
- Very frequent (80% to 99% of cases)
- Increased circulating gonadotropin level
Show the remaining 5
- Pleural effusionHPOHP:0002202
- Frequent (30% to 79% of cases)
- Generalized edemaHPOHP:0007430
- Occasional (5% to 29% of cases)
- HypovolemiaHPOHP:0011106
- Occasional (5% to 29% of cases)
- Peripheral edemaHPOHP:0012398
- Occasional (5% to 29% of cases)
- Pulmonary edemaHPOHP:0100598
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FSHRHGNC:3969
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
- Strong · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
1 name
Resolves to: ovarian hyperstimulation syndrome
- Also called
- OHSS