non-secreting paraganglioma
Findings
No curated finding names non-secreting paraganglioma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Non-functioning paraganglioma is a rare neuroendocrine tumor arising from neural crest-derived paraganglion cells (most often in the para-aortic region at the level of renal hilia, organ of Zuckerkandl, thoracic paraspinal region, bladder, and carotid body) not associated with catecholamine secretion. These tumors are usually clinically silent and symptoms, if present, are nonspecific and depend on the location of the tumor. Association with certain hereditary cancer-predisposing syndromes, such as multiple endocrine neoplasia, neurofibromatosis type 1 or von Hippel Lindau syndrome, may be observed.
Definition from the Mondo Disease Ontology (MONDO:0019788), read 2026-09-29. CC BY 4.0.
Features
31 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ParagangliomaHPOHP:0002668
- Very frequent (80% to 99% of cases)
- Cerebral hemorrhageHPOHP:0001342
- Frequent (30% to 79% of cases)
- Chest painHPOHP:0100749
- Frequent (30% to 79% of cases)
- DysphoniaHPOHP:0001618
- Frequent (30% to 79% of cases)
- Elevated urinary dopamine levelHPOHP:0011979
- Frequent (30% to 79% of cases)
- Elevated urinary epinephrine levelHPOHP:0003639
- Frequent (30% to 79% of cases)
- Elevated urinary norepinephrine level
Show the remaining 19
- Hypertension associated with pheochromocytomaHPOHP:0002640
- Frequent (30% to 79% of cases)
- Hypertensive retinopathyHPOHP:0001095
- Frequent (30% to 79% of cases)
- NauseaHPOHP:0002018
- Frequent (30% to 79% of cases)
- PalpitationsHPOHP:0001962
- Frequent (30% to 79% of cases)
- Paraganglioma of head and neckHPOHP:0002864
- Frequent (30% to 79% of cases)
- Paroxysmal vertigoHPOHP:0010532
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
- Narrower terms (1)