narcolepsy 1
Findings
No curated finding names narcolepsy 1 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare disorder characterized by sudden and transient episodes of loss of muscle tone. It often follows an experience of intense emotions. It is seen in patients with narcolepsy.
Definition from the Mondo Disease Ontology (MONDO:0008062), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Infantile onset
HPO, annotations 2026-09-02
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Excessive daytime somnolenceHPOHP:0001262
- 1 of 1 reported patient
- Hypnagogic hallucinationHPOHP:0002519
- 1 of 1 reported patient
- CataplexyHPOHP:0002524
- 39 of 40 reported patients
- Sleep paralysisHPOHP:0025233
- 31 of 40 reported patients
- Poor sleepHPOHP:4000064
- 24 of 39 reported patients
- Sleep onset rapid eye movement periodHPOHP:5200356
- 24 of 39 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- HCRTHGNC:4847
- Limited · Ambry Genetics · Autosomal dominant · 2024
- Limited · PanelApp Australia · Autosomal dominant · 2025
- No Known Disease Relationship · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2018
Where it sits
Other names
2 names
Resolves to: narcolepsy 1
- Also called
- HCRT narcolepsynarcolepsy caused by mutation in HCRT