meningioma
Findings
No curated finding names meningioma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)
Definition from the Mondo Disease Ontology (MONDO:0016642), read 2026-09-29. CC BY 4.0.
Features
74 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Chromosomal breakage induced by ionizing radiationHPOHP:0010997
- Very frequent (80% to 99% of cases)
- Increased sensitivity to ionizing radiationHPOHP:0011133
- Very frequent (80% to 99% of cases)
- Intracranial meningiomaHPOHP:0100009
- Very frequent (80% to 99% of cases)
- Abnormal brain FDG positron emission tomographyHPOHP:0012658
- Frequent (30% to 79% of cases)
- AmenorrheaHPOHP:0000141
- Frequent (30% to 79% of cases)
- Bitemporal hemianopiaHPOHP:0030521
- Frequent (30% to 79% of cases)
Show the remaining 62
- Focal T2 hypointense thalamic lesionHPOHP:0012691
- Frequent (30% to 79% of cases)
- Focal-onset seizureHPOHP:0007359
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- Hypogonadotropic hypogonadismHPOHP:0000044
- Frequent (30% to 79% of cases)
- ImpotenceHPOHP:0000802
- Frequent (30% to 79% of cases)
- Increased circulating prolactin concentrationHPOHP:0000870
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- NTHL1HGNC:8028
- Limited · Ambry Genetics · Autosomal recessive · 2024
Where it sits
- A kind of
- Narrower terms (37)
- angiomatous meningioma
- anterior cranial fossa meningioma
- benign meningioma
- clear cell meningioma
- familial meningioma
- fibrous meningioma
- gasserian ganglion meningioma
- grade II meningioma
- grade III meningioma
- intracranial meningioma
- intraorbital meningioma
- intraspinal meningioma
- intraventricular meningioma
- jugular foramen meningioma
- lung meningioma
- lymphoplasmacyte-rich meningioma
- malignant leptomeningeal tumor
- meningothelial meningioma
- microcystic meningioma
- middle cranial fossa meningioma
- optic nerve sheath meningioma
- optic tract meningioma
- papillary meningioma
Other names
1 name
Resolves to: meningioma
- Also called
- meningioma (disease)