melanoma
Findings
No curated finding names melanoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.
Definition from the Mondo Disease Ontology (MONDO:0005105), read 2026-09-29. CC BY 4.0.
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of
- Narrower terms (15)
- amelanotic melanoma
- CDK4 linked melanoma
- childhood malignant melanoma
- cutaneous melanoma
- epithelioid cell melanoma
- familial melanoma
- malignant breast melanoma
- malignant melanoma of the mucosa
- melanomatosis
- metastatic melanoma
- mixed epithelioid and spindle cell melanoma
- non-cutaneous melanoma
- ocular melanoma
- scrotum melanoma
- spindle cell melanoma
Other names
3 names
Resolves to: melanoma
- Also called
- malignant melanomamelanoma (disease)melanoma, malignant