isolated trigonocephaly
Findings
No curated finding names isolated trigonocephaly yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Isolated trigonocephaly is a nonsyndromic form of craniosynostosis characterized by the premature fusion of the metopic suture.
Definition from the Mondo Disease Ontology (MONDO:0018065), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Metopic synostosisHPOHP:0011330
- Very frequent (80% to 99% of cases)
- TrigonocephalyHPOHP:0000243
- Very frequent (80% to 99% of cases)
- Highly arched eyebrowHPOHP:0002553
- Frequent (30% to 79% of cases)
- HypotelorismHPOHP:0000601
- Frequent (30% to 79% of cases)
- Narrow foreheadHPOHP:0000341
- Frequent (30% to 79% of cases)
- Prominent supraorbital ridgesHPOHP:0000336
- Frequent (30% to 79% of cases)
- SynophrysHPOHP:0000664
- Frequent (30% to 79% of cases)
- Wide nasal bridgeHPOHP:0000431
- Frequent (30% to 79% of cases)
- Delayed speech and language developmentHPOHP:0000750
- Occasional (5% to 29% of cases)
- OmphaloceleHPOHP:0001539
- Occasional (5% to 29% of cases)
- Increased intracranial pressureHPOHP:0002516
- Very rare (1% to 4% of cases)
- PapilledemaHPOHP:0001085
- Very rare (1% to 4% of cases)
Show the remaining 1
- StrabismusMondoHP:0000486
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- Narrower terms (2)
Other names
2 names
Resolves to: isolated trigonocephaly
- Also called
- non-syndromic metopic craniosynostosisnonsyndromic trigonocephaly