hypokalemic periodic paralysis
Findings
No curated finding names hypokalemic periodic paralysis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Hypokalemic periodic paralysis (hypoPP) is characterized by episodes of muscle paralysis lasting from a few to 24-48 hours and associated with a fall in blood potassium levels.
Definition from the Mondo Disease Ontology (MONDO:0008223), read 2026-09-29. CC BY 4.0.
Features
20 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Episodic hypokalemiaHPOHP:0012726
- Obligate (100% of cases)
- Periodic hypokalemic paresisHPOHP:0008153
- Obligate (100% of cases)
- Abnormal muscle fiber morphologyHPOHP:0004303
- Very frequent (80% to 99% of cases)
- EMG abnormalityHPOHP:0003457
- Very frequent (80% to 99% of cases)
- Episodic flaccid weaknessHPOHP:0003752
- Very frequent (80% to 99% of cases)
- Increased intramyocellular lipid dropletsHPOHP:0012240
- Very frequent (80% to 99% of cases)
- Mildly elevated creatine kinaseHPOHP:0008180
- Very frequent (80% to 99% of cases)
- ParalysisHPOHP:0003470
- Very frequent (80% to 99% of cases)
- Diminished deep tendon reflexHPOHP:0001315
- Frequent (30% to 79% of cases)
- Exercise-induced muscle fatigueHPOHP:0009020
- Frequent (30% to 79% of cases)
- Postprandial hyperglycemiaHPOHP:0011998
- Frequent (30% to 79% of cases)
- ArrhythmiaHPOHP:0011675
- Occasional (5% to 29% of cases)
Reported absent (2)
- Impaired myocardial contractilityHPOHP:0006670
- MyotoniaHPOHP:0002486
Show the remaining 8
- Fatty replacement of skeletal muscleHPOHP:0012548
- Occasional (5% to 29% of cases)
- Late-onset proximal muscle weaknessHPOHP:0003694
- Occasional (5% to 29% of cases)
- Muscle spasmHPOHP:0003394
- Occasional (5% to 29% of cases)
- PainHPOHP:0012531
- Occasional (5% to 29% of cases)
- Respiratory insufficiency due to muscle weaknessHPOHP:0002747
- Occasional (5% to 29% of cases)
- Adrenocortical adenomaHPOHP:0008256
- Very rare (1% to 4% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
5 names
Resolves to: hypokalemic periodic paralysis
- Also called
- familial periodic paralysis (& [hypokalaemic])HKPPHOKPPHypoPPWestphall disease