hereditary nonpolyposis colon cancer
Findings
No curated finding names hereditary nonpolyposis colon cancer yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A cancer-predisposing condition characterized by the development of colorectal cancer not associated with colorectal polyposis, endometrial cancer, and various other cancers (such as malignant epithelial tumor of ovary, gastric, biliary tract, small bowel, and urinary tract cancer) that are frequently diagnosed at an early age.
Definition from the Mondo Disease Ontology (MONDO:0018630), read 2026-09-29. CC BY 4.0.
Genes
12 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ATMHGNC:795
- Limited · Ambry Genetics · Autosomal dominant · 2024
- CDKN1BHGNC:1785
- Limited · ClinGen · Unknown · 2017
- CHEK2HGNC:16627
- Limited · ClinGen · Unknown · 2017
- EPHX1HGNC:3401
- Limited · ClinGen · Unknown · 2016
- FAN1HGNC:29170
- Limited · ClinGen · Unknown · 2017
- NFKBIZHGNC:29805
- Limited · ClinGen · Unknown · 2017
- PTPRJHGNC:9673
Where it sits
Other names
6 names
Resolves to: hereditary nonpolyposis colon cancer
- Also called
- colorectal cancer, hereditary nonpolyposisfamilial nonpolyposis colon cancerfamilial nonpolyposis colorectal cancerhereditary nonpolyposis colorectal cancerHereditary nonpolyposis colorectal cancer (HNPCC)HNPCC