graft versus host disease
MONDO:0013730Mondo
Findings
No curated finding names graft versus host disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An immune system disorder that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.
Definition from the Mondo Disease Ontology (MONDO:0013730), read 2026-09-29. CC BY 4.0.
Features
41 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Inflammatory abnormality of the skinHPOHP:0011123
- Very frequent (80% to 99% of cases)
- Chronic hepatitisHPOHP:0200123
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Frequent (30% to 79% of cases)
- Maculopapular exanthemaHPOHP:0040186
- Frequent (30% to 79% of cases)
- Oral ulcerHPOHP:0000155
- Frequent (30% to 79% of cases)
- Recurrent infectionsHPOHP:0002719
- Frequent (30% to 79% of cases)
- Skin erosionHPOHP:0200041
- Frequent (30% to 79% of cases)
- StomatitisHPOHP:0010280
- Frequent (30% to 79% of cases)
- Abdominal painHPOHP:0002027
- Occasional (5% to 29% of cases)
- Acute hepatitisHPOHP:0200119
- Occasional (5% to 29% of cases)
- ArthritisHPOHP:0001369
- Occasional (5% to 29% of cases)
Show the remaining 29
- Cutaneous sclerotic plaqueHPOHP:0031359
- Occasional (5% to 29% of cases)
- Elevated circulating alkaline phosphatase concentrationHPOHP:0003155
- Occasional (5% to 29% of cases)
- FasciitisHPOHP:0100537
- Occasional (5% to 29% of cases)
- Gastrointestinal inflammationHPOHP:0004386
- Occasional (5% to 29% of cases)
- HemophagocytosisHPOHP:0012156
- Occasional (5% to 29% of cases)
- HepatosplenomegalyHPOHP:0001433
- Occasional (5% to 29% of cases)
Where it sits
- Narrower terms (2)
Other names
12 names
Resolves to: graft versus host disease
- Also called
- disease, graft-versus-hostdisease, graft-vs-hostdiseases, graft-versus-hostdiseases, graft-vs-hostgraft vs host diseasegraft vs. host diseasegraft-versus-host diseasegraft-versus-host-diseasegraft-vs-host diseaseGVHGVHDrunt disease