chronic graft versus host disease
Findings
No curated finding names chronic graft versus host disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Chronic graft versus host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body. Symptoms may include skin rash, mouth sores, dry eyes, liver inflammation, development of scar tissue in the skin and joints, and damage to the lungs. The exact cause of chronic GVHD is unknown.It likely results from a complex immune-mediated interaction between the donor and recipient cells.Chronic GVHD is treated with prednisone or other similar anti-inflammatory or immunosuppressive medications.
Definition from the Mondo Disease Ontology (MONDO:0020547), read 2026-09-29. CC BY 4.0.
Features
53 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Intermittent generalized erythematous papular rashHPOHP:0007432
- Very frequent (80% to 99% of cases)
- Poor wound healingHPOHP:0001058
- Very frequent (80% to 99% of cases)
- Thickened skinHPOHP:0001072
- Very frequent (80% to 99% of cases)
- Abnormal skin pigmentationHPOHP:0001000
- Frequent (30% to 79% of cases)
- AlopeciaHPOHP:0001596
- Frequent (30% to 79% of cases)
- BronchiectasisHPOHP:0002110
- Frequent (30% to 79% of cases)
- Elevated circulating hepatic transaminase concentration
Show the remaining 41
- PhotophobiaHPOHP:0000613
- Frequent (30% to 79% of cases)
- Recurrent corneal erosionsHPOHP:0000495
- Frequent (30% to 79% of cases)
- Recurrent infectionsHPOHP:0002719
- Frequent (30% to 79% of cases)
- XerostomiaHPOHP:0000217
- Frequent (30% to 79% of cases)
- Abdominal painHPOHP:0002027
- Occasional (5% to 29% of cases)
- Abnormal esophagus morphologyHPOHP:0002031
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: chronic graft versus host disease
- Also called
- graft versus host disease, chronicGVHD, chronic