focal segmental glomerulosclerosis 8
Findings
No curated finding names focal segmental glomerulosclerosis 8 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any focal segmental glomerulosclerosis in which the cause of the disease is a mutation in the ANLN gene.
Definition from the Mondo Disease Ontology (MONDO:0014462), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Late onset · Juvenile onset · Young adult onset
HPO, annotations 2026-09-02
Features
4 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Focal segmental glomerulosclerosisHPOHP:0000097
- 9 of 9 reported patients
- ProteinuriaHPOHP:0000093
- 5 of 5 reported patients
- Stage 5 chronic kidney diseaseHPOHP:0003774
- 6 of 6 reported patients · Adult onset
- Nephrotic syndromeHPOHP:0000100
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ANLNHGNC:14082
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- Limited · Ambry Genetics · Autosomal dominant · 2022
Where it sits
Other names
4 names
Resolves to: focal segmental glomerulosclerosis 8
- Also called
- ANLN focal segmental glomerulosclerosisfocal segmental glomerulosclerosis caused by mutation in ANLNfocal segmental glomerulosclerosis type 8FSGS8